Because no loss-of-function mutations in the 3 gene could be found in the MMIH patients examined (Lev-Lehman et al
Because no loss-of-function mutations in the 3 gene could be found in the MMIH patients examined (Lev-Lehman et al., 2001), other protein deficits could underlie the syndrome. UBXD4 led to a significant reduction of 3* nAChRs in rat cortical neurons and dPC12 cells. Biochemical and immunofluorescence studies of endogenous UBXD4 showed that this protein is… Read More »